PHILADELPHIA—Researchers at Thomas Jefferson University have found that colonoscopy preparation drugs administered the same day as the procedure are equally effective to those given the night before and the morning of the procedure, but result in fewer complaints of side effects such as abdominal pain, sleep loss and workday interference.
The randomized, single blind study, compared results between 116 colonoscopy patients given a split dosage of colon preparation the night before and morning of their colonoscopy and those given the colonoscopy preparation solely the morning of their colonoscopy. The study shows that both treatments are clinically equal. Primary Investigator David Kastenberg, MD, department of Gastroenterology and Hepatology at Jefferson Medical College of Thomas Jefferson University and his co-authors present their findings in the current online edition of the American Journal of Gastroenterology.
“The most important thing to consider during a colonoscopy are clear images,” said Kastenberg. “During the procedure I want to be able to have the best view to ensure that nothing is missed and all abnormalities are scrutinized. That’s why the colon prep is so important. For years patients have been taking the colon prep solution the night before and had successful colonoscopies the following day but had to endure numerous side effects. Recently, the American College of Gastroenterology endorsed split dosing, which means patients need to experience all the side effects of a colon prep both at night and on the morning of the colonoscopy. What we looked at was can we administer the colon prep the same day and get equal results without the side effects? The answer is yes. The images are just as good when giving the colon prep the day of the procedure than they are when giving the colon prep as a split dose on both days, while reducing and in some cases eliminating the side effects.”