LONDON—A new study published in British Medical Journal conducted by investigators at two large hospitals in The Netherlands shows that a trained dog was able to detect Clostridium difficile with high estimated sensitivity and specificity, both in stool samples and in hospital patients infected with C. difficile.
Bomers, et al. (2012) conducted this proof of principle study using a case-control design. A 2-year-old beagle was trained to identify the smell of C difficile and tested on 300 patients (30 with C difficile infection and 270 controls). According to the researchers, the dog was guided along the wards by its trainer, who was blinded to the participants’ infection status. Each detection round concerned 10 patients (one case and nine controls). The dog was trained to sit or lie down when C. difficile was detected.
Main outcome measures were sensitivity and specificity for detection of C difficile in stool samples and in patients. The dog’s sensitivity and specificity for identifying C difficile in stool samples were both 100 percent (95 percent confidence interval 91 percent to 100 percent). During the detection rounds, the dog correctly identified 25 of the 30 cases (sensitivity 83 percent, 65 percent to 94 percent) and 265 of the 270 controls (specificity 98 percent, 95 percent to 99 percent).
Reference: Bomers MK, et al. Using a dog’s superior olfactory sensitivity to identify Clostridium difficile in stools and patients: proof of principle study. British Medical Journal. December 2012; 345.